Comparison of Exercise Intensity Effects on Irisin Serum Levels and Lipid Profiles in Obese Adolescents

Abstract

Objective: Irisin is a myokine that has a beneficial effect on obesity by increasing energy expenditure. The aim of this study was to compare the effect of exercise intensity on serum irisin levels and lipid profile in obese adolescents.

Materials and Methods: Forty-six male students with an average age of 13.43 ± 0.77 years; height 163.18 ± 23 cm, weight 85.84 ± 8.46 kg, body fat percentage 37.001 ± 4.508 were randomly assigned to three groups: low-intensity activity (experimental 1), high-intensity activity (experimental 2), and control. The training program in experimental group 1 included running at 45-60% heart rate reserve intensity, and in experimental group 2, it was similar to group 1 along with combined exercises at 60-75% heart rate reserve intensity, performed 4 sessions per week for 10 weeks. A paired t-test was used to examine within-group differences, and Mixed ANOVA was used to examine between-group differences. All tests were conducted at a significance level of 0.05 using SPSS22 software.

Results: The findings indicated a significant decrease in serum irisin levels in both experimental groups 1 and 2 (p < 0.001). Additionally, weight, body fat percentage, and low-density lipoprotein significantly decreased in both experimental groups. Cholesterol and LDL/HDL ratio only significantly decreased in the high-intensity group.

Conclusion: Considering the impact of exercise at both intensities on weight, body fat percentage, and irisin levels, regular physical activity is recommended for adolescents.